Is early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND/PURPOSE: Atherosclerosis and vascular stiffness have been implicated in the pathogenesis of age-related macular degeneration (AMD). The association of carotid artery stiffness, a measure of arterial elasticity reflecting early atherosclerosis, with early AMD, was examined in this study. METHODS: A population-based, cross-sectional study of 9954 middle-aged people (age range 51-72 years). The presence of AMD signs was determined from fundus photographs according to the Wisconsin grading protocol. Carotid arterial stiffness was measured from high-resolution ultrasonic echo tracking of the left common carotid artery, and was defined as an adjusted arterial diameter change (AADCmu). A smaller AADC reflects greater carotid artery stiffness. The associations of pulse pressure and carotid artery intima-media thickness (IMT) with early AMD signs were also analysed. RESULTS: In the study population, 454 (4.6%) had early AMD. The mean (SD) AADC was 403 (127) mu. After adjusting for age, sex, race/centre, education, cigarette smoking, fasting glucose, lipid profile and inflammatory markers, a smaller AADC was found to be not associated with early AMD (odds ratio 0.94; 95% confidence interval, 0.71 to 1.25) or its component lesions. Other measures of arterial stiffness (pulse pressure) and atherosclerosis (carotid IMT) were also not associated with early AMD. CONCLUSIONS: Carotid artery stiffness was not associated with signs of early AMD in this middle-aged population. These data provide no evidence of a link between age-related elastoid changes and early atherosclerotic processes in the carotid arteries and early AMD.

Full Text

Duke Authors

Cited Authors

  • Cheung, N; Liao, D; Islam, FMA; Klein, R; Wang, JJ; Wong, TY

Published Date

  • April 2007

Published In

Volume / Issue

  • 91 / 4

Start / End Page

  • 430 - 433

PubMed ID

  • 17035267

Pubmed Central ID

  • PMC1994729

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjo.2006.106054


  • eng

Conference Location

  • England