A questionnaire-based assessment of symptoms associated with tear film dysfunction and lid margin disease in an Asian population.

Journal Article (Journal Article)

PURPOSE: To study the prevalence, associated factors and impact of symptomatic dry eye in an Asian population. METHODS: A population based survey of eye diseases in 3,280 (78.7% response rate) Malay persons aged 40-80 selected from designated areas in southwestern Singapore. Participants were administered a standardized dry eye questionnaire consisting of 6 questions on symptoms, and had a comprehensive systemic and ocular examination. Symptoms of tear film dysfunction (STFD) was defined as one or more self-reported symptoms that were frequently present (ranked often or all the time). RESULTS: The prevalence rate of STFD was 6.5% (95% confidence interval [CI]: 5.7, 7.4). The prevalence was significantly higher in men compared to women (8.2% and 4.9%, respectively; p < 0.001) and decreased with age in men (p = 0.002) but not in women (p = 0.101). After adjusting for age, gender, nature of work (outdoor/indoor), and housing type, factors significantly associated with STFD were cigarette smoking (odds ratio [OR] 1.77, 95% CI: 1.17-2.66), thyroid disease (OR 2.58; 95% CI: 1.29-5.18) and higher income (OR 1.74; 95% CI: 1.13-2.68). STFD were associated with self-reported difficulty in performing daily activities (work, family and leisure related) (p = 0.006). CONCLUSION: STFD are present in 6.5% of Singapore Malay adults and is associated with cigarette smoking, presence of thyroid disease and a reduced visual function-related quality of life.

Full Text

Duke Authors

Cited Authors

  • Tong, L; Saw, S-M; Lamoureux, EL; Wang, JJ; Rosman, M; Tan, DTH; Wong, TY

Published Date

  • January 2009

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 31 - 37

PubMed ID

  • 19191179

Electronic International Standard Serial Number (EISSN)

  • 1744-5086

Digital Object Identifier (DOI)

  • 10.1080/09286580802521317


  • eng

Conference Location

  • England