Prevalence and risk factors of retinal arteriolar emboli: the Singapore Malay Eye Study.

Published

Journal Article

PURPOSE: To examine the prevalence and risk factors of retinal arteriolar emboli, a risk predictor of stroke, in an Asian population. DESIGN: Population-based cross-sectional study. METHODS: Retinal emboli were ascertained from retinal photographs obtained from both eyes of 3,265 Asian Malays, aged 40 to 80 years, according to a standardized protocol. Risk factors were assessed from detailed standardized interviews, clinical examinations, and laboratory investigations. RESULTS: The overall prevalence of retinal emboli was 0.6% (95% confidence interval [CI], 0.58 to 0.62). A finding of retinal emboli was strongly associated with increasing age (P = .005, for trend), but age-stratified prevalence rates were still lower than those reported from previous population-based studies of White persons. After adjusting for age and gender, the presence of retinal emboli was associated with cigarette smoking (odds ratio [OR], 5.96; 95% CI, 1.75 to 20.32), elevated total cholesterol (OR, 5.21; 95% CI, 1.93 to 12.82), low-density lipoprotein cholesterol (OR, 2.98; 95% CI, 1.20 to 7.39), and self-reported history of angina (OR, 5.67; 95% CI, 1.62 to 19.91). These associations remained significant in multivariate analysis with additional adjustment for other risk factors. CONCLUSIONS: Retinal emboli are less common in Asians than in similarly aged White persons, but are associated with similar cardiovascular risk factors.

Full Text

Duke Authors

Cited Authors

  • Cheung, N; Lim, L; Wang, JJ; Islam, FMA; Mitchell, P; Saw, SM; Aung, T; Wong, TY

Published Date

  • October 2008

Published In

Volume / Issue

  • 146 / 4

Start / End Page

  • 620 - 624

PubMed ID

  • 18639861

Pubmed Central ID

  • 18639861

Electronic International Standard Serial Number (EISSN)

  • 1879-1891

Digital Object Identifier (DOI)

  • 10.1016/j.ajo.2008.05.033

Language

  • eng

Conference Location

  • United States