Convex hull based neuro-retinal optic cup ellipse optimization in glaucoma diagnosis.


Conference Paper

Glaucoma is the second leading cause of blindness. Glaucoma can be diagnosed through measurement of neuro-retinal optic cup-to-disc ratio (CDR). Automatic calculation of optic cup boundary is challenging due to the interweavement of blood vessels with the surrounding tissues around the cup. A Convex Hull based Neuro-Retinal Optic Cup Ellipse Optimization algorithm improves the accuracy of the boundary estimation. The algorithm's effectiveness is demonstrated on 70 clinical patient's data set collected from Singapore Eye Research Institute. The root mean squared error of the new algorithm is 43% better than the ARGALI system which is the state-of-the-art. This further leads to a large clinical evaluation of the algorithm involving 15 thousand patients from Australia and Singapore.

Full Text

Duke Authors

Cited Authors

  • Zhang, Z; Liu, J; Cherian, NS; Sun, Y; Lim, JH; Wong, WK; Tan, NM; Lu, S; Li, H; Wong, TY

Published Date

  • 2009

Published In

Volume / Issue

  • 2009 /

Start / End Page

  • 1441 - 1444

PubMed ID

  • 19963748

Pubmed Central ID

  • 19963748

International Standard Serial Number (ISSN)

  • 1557-170X

Digital Object Identifier (DOI)

  • 10.1109/IEMBS.2009.5332913

Conference Location

  • United States