Emerging therapeutic approaches in the management of retinal angiogenesis and edema.

Journal Article (Review)

Conditions resulting in retinal angiogenesis and edema (exudative age-related macular degeneration, diabetic retinopathy, retinal vein occlusion and retinopathy of prematurity) are major causes of visual impairment, with significant impact on quality of life. There has been increasing clinical usage of anti-vascular endothelial growth factor (anti-VEGF) agents to stop retinal angiogenesis and resolve intraretinal fluid arising from these conditions. However, anti-VEGFs have not been completely successful in curing these conditions, and a range of emerging treatments aimed at supplementing or competing with anti-VEGF agents are being developed. We will discuss the proposed merits these emerging agents bring to the treatment arsenal and how they compare with anti-VEGFs with regards to therapeutic activity, potency, specificity and safety. This review will also highlight recent pre-clinical research findings and suggest where future research might be directed.

Full Text

Duke Authors

Cited Authors

  • Truong, A; Wong, TY; Khachigian, LM

Published Date

  • April 2011

Published In

Volume / Issue

  • 89 / 4

Start / End Page

  • 343 - 361

PubMed ID

  • 21170513

Pubmed Central ID

  • 21170513

Electronic International Standard Serial Number (EISSN)

  • 1432-1440

Digital Object Identifier (DOI)

  • 10.1007/s00109-010-0709-z


  • eng

Conference Location

  • Germany