Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study.

Journal Article (Journal Article)

The purpose of this study is to determine whether the angiotensin-converting enzyme (ACE) gene polymorphism is associated with retinal arteriolar narrowing, a subclinical marker of chronic hypertension. The Funagata Study examined a population-based sample of Japanese aged 35+ years; 368 participants had both retinal vessel diameter measurements and ACE insertion/deletion (ACE I/D) polymorphism analyses performed. Assessment of retinal vessel diameter and retinal vessel wall signs followed the protocols used in the Blue Mountains Eye Study. ACE gene polymorphisms D/D, I/D and I/I were present in 34 (9.2%), 170 (46.2%) and 164 (44.5%) participants, respectively, distributed in Hardy-Weinberg equilibrium. After multivariable adjustment, retinal arteriolar diameter was significantly narrower in subjects with the D/D genotype compared to subjects with I/D and I/I genotypes (mean difference -6.49 microm, 95% confidence interval (CI): -12.86 microm, -0.11 microm). Our study suggests that the ACE I/D polymorphism may be associated with subclinical structural arteriolar changes related to chronic hypertension.

Full Text

Duke Authors

Cited Authors

  • Tanabe, Y; Kawasaki, R; Wang, JJ; Wong, TY; Mitchell, P; Daimon, M; Oizumi, T; Kato, T; Kawata, S; Kayama, T; Yamashita, H

Published Date

  • December 2009

Published In

Volume / Issue

  • 23 / 12

Start / End Page

  • 788 - 793

PubMed ID

  • 19369957

Pubmed Central ID

  • PMC2834325

Electronic International Standard Serial Number (EISSN)

  • 1476-5527

Digital Object Identifier (DOI)

  • 10.1038/jhh.2009.27


  • eng

Conference Location

  • England