Is diabetic retinopathy an independent risk factor for ischemic stroke?

Journal Article (Journal Article)

BACKGROUND AND PURPOSE: The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS: A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic stroke events were prospectively identified and validated. RESULTS: Over an average follow-up of 7.8 years, there were 75 ischemic stroke events. After adjustment for age, gender, race, center, 6-year mean arterial blood pressure, anti-hypertensive treatment use, fasting glucose, insulin treatment, duration of diabetes, high-density lipoprotein and low-density lipoprotein cholesterol levels and cigarette smoking status, diabetic retinopathy was associated with an increased risk of ischemic stroke (hazard rate ratio, 2.34; 95% CI, 1.13 to 4.86). CONCLUSIONS: Diabetic retinopathy predicts incident ischemic stroke in people with diabetes, independent of other risk factors.

Full Text

Duke Authors

Cited Authors

  • Cheung, N; Rogers, S; Couper, DJ; Klein, R; Sharrett, AR; Wong, TY

Published Date

  • February 2007

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 398 - 401

PubMed ID

  • 17194880

Electronic International Standard Serial Number (EISSN)

  • 1524-4628

Digital Object Identifier (DOI)

  • 10.1161/01.STR.0000254547.91276.50


  • eng

Conference Location

  • United States