Association between physical activity and retinal microvascular signs: the Atherosclerosis Risk in Communities (ARIC) Study.

Journal Article (Journal Article)

OBJECTIVE: To examine the association between physical activity measured during leisure, sport, and work and retinal microvascular signs. METHODS: Participants of the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cross-sectional study, had retinal photographs taken at their third follow up visit (1993-1995). Retinal microvascular signs were assessed using a standardized protocol and retinal vascular caliber by a computer-assisted method. Leisure, sport, and work-related physical activity levels were determined through a modified Baecke physical activity questionnaire. RESULTS: A higher level of physical activity during sport and work was significantly associated with a lower prevalence of arteriovenous (AV) nicking, wider venular caliber, and retinopathy. In multivariate models, persons with a level of sport-related physical activity above the median were less likely to have AV nicking (odds ratio [OR] = 0.87; 95% confidence interval [CI] 0.78-0.97) and wider retinal venules (OR = 0.91; 95% CI: 0.83-0.99). Persons with a level of work-related physical activity above the median were less likely to have diabetic retinopathy (OR = 0.66, 95% CI: 0.51-0.85). CONCLUSIONS: In this cross-sectional analyzes, higher levels of physical activity was associated with a lower prevalence of retinal microvascular abnormalities.

Full Text

Duke Authors

Cited Authors

  • Tikellis, G; Anuradha, S; Klein, R; Wong, TY

Published Date

  • July 2010

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 381 - 393

PubMed ID

  • 20618695

Pubmed Central ID

  • PMC3005356

Electronic International Standard Serial Number (EISSN)

  • 1549-8719

Digital Object Identifier (DOI)

  • 10.1111/j.1549-8719.2010.00033.x


  • eng

Conference Location

  • United States