Alterations in retinal microvascular geometry in young type 1 diabetes.

Journal Article

OBJECTIVE: To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Patients with type 1 diabetes (aged 12-20 years) had clinical assessments and retinal photography following standardized protocol at a tertiary-care hospital in Sydney. Retinal microvascular geometry, including arteriolar and venular tortuosity, branching angles, optimality deviation, and length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these geometric characteristics with diabetes duration, A1C level, systolic blood pressure (SBP), and other risk factors were assessed. RESULTS: Of 1,159 patients enrolled, 944 (81.4%) had gradable photographs and 170 (14.7%) had retinopathy. Older age was associated with decreased arteriolar (P = 0.024) and venular (P = 0.002) tortuosity, and female subjects had larger arteriolar branching angle than male subjects (P = 0.03). After adjusting for age and sex, longer diabetes duration was associated with larger arteriolar branching angle (P 8.5 vs.

Full Text

Duke Authors

Cited Authors

  • Sasongko, MB; Wang, JJ; Donaghue, KC; Cheung, N; Benitez-Aguirre, P; Jenkins, A; Hsu, W; Lee, M-L; Wong, TY

Published Date

  • June 2010

Published In

Volume / Issue

  • 33 / 6

Start / End Page

  • 1331 - 1336

PubMed ID

  • 20299479

Pubmed Central ID

  • 20299479

Electronic International Standard Serial Number (EISSN)

  • 1935-5548

Digital Object Identifier (DOI)

  • 10.2337/dc10-0055

Language

  • eng

Conference Location

  • United States