Effect of blood pressure on the retinal vasculature in a multi-ethnic Asian population.

Published

Journal Article

Blood pressure has a significant effect on retinal arterioles. There are few data on whether this effect varies by race/ethnicity. We examined the relationship of blood pressure and retinal vascular caliber in a multi-ethnic Asian population. The study is population-based and cross sectional in design. A total of 3749 Chinese, Malay and Indian participants aged > or =24 years residing in Singapore were included in the study. Retinal vascular caliber was measured using a computer program from digital retinal photographs. The associations of retinal vascular caliber with blood pressure and hypertension in each racial/ethnic group were analyzed. The main outcome measures are retinal arteriolar caliber and venular caliber. The results show that retinal arterioles were narrower in persons with uncontrolled/untreated hypertension (140.0 microm) as compared with persons with controlled hypertension (142.1 microm, P=0.0001) and those with no hypertension (146.0 microm, P<0.0001). On controlling for age, gender, body mass index, lipids and smoking, each 10 mm Hg increase in mean arterial blood pressure was associated with a 3.1 microm decrease in arteriolar caliber (P<0.0001), with a similar magnitude seen in all three racial/ethnic groups: 3.1 microm in Chinese, 2.8 microm in Malays and 3.2 microm in Indians (P<0.0001 for all). Each 10 mm Hg increase in mean arterial blood pressure was associated with a 1.8 microm increase in venular caliber (P<0.0001); furthermore, the magnitude of this effect was similar across the three racial/ethnic groups. The effect of blood pressure on the retinal vasculature was similar across three major racial/ethnic groups in Asia.

Full Text

Duke Authors

Cited Authors

  • Jeganathan, VSE; Sabanayagam, C; Tai, ES; Lee, J; Sun, C; Kawasaki, R; Nagarajan, S; Huey-Shi, MH; Sandar, M; Wong, TY

Published Date

  • November 2009

Published In

Volume / Issue

  • 32 / 11

Start / End Page

  • 975 - 982

PubMed ID

  • 19713968

Pubmed Central ID

  • 19713968

Electronic International Standard Serial Number (EISSN)

  • 1348-4214

Digital Object Identifier (DOI)

  • 10.1038/hr.2009.130

Language

  • eng

Conference Location

  • England