Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.

Journal Article (Journal Article)

OBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD). METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders. RESULTS: The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82). CONCLUSIONS: Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.

Full Text

Duke Authors

Cited Authors

  • Peeters, A; Magliano, DJ; Stevens, J; Duncan, BB; Klein, R; Wong, TY

Published Date

  • November 2008

Published In

Volume / Issue

  • 126 / 11

Start / End Page

  • 1554 - 1560

PubMed ID

  • 19001224

Pubmed Central ID

  • PMC5774859

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

Digital Object Identifier (DOI)

  • 10.1001/archopht.126.11.1554


  • eng

Conference Location

  • United States