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Dietary glycemic index and the risk of age-related macular degeneration.

Publication ,  Journal Article
Kaushik, S; Wang, JJ; Flood, V; Tan, JSL; Barclay, AW; Wong, TY; Brand-Miller, J; Mitchell, P
Published in: Am J Clin Nutr
October 2008

BACKGROUND: Dietary factors are known risk factors for age-related macular degeneration (AMD) -- the leading cause of visual loss among persons aged > or =65 y. High-glycemic-index diets have been hypothesized as a risk factor for AMD, but prospective data are unavailable. OBJECTIVE: The objective was to examine the association between dietary glycemic index and the 10-y incidence of AMD in the Blue Mountain Eye Study population. DESIGN: This was a population-based cohort study with 3,654 participants (> or =49 y) examined at baseline (1992-1994); 2,335 patients were reexamined after 5 y and 1952 after 10 y. The Wisconsin System was used to grade 10-y incident early and late AMD from retinal photographs. A food-frequency questionnaire was used to collect dietary information at baseline, and an Australian database was used to calculate the mean glycemic index. RESULTS: Over 10 y, 208 of 1,810 persons (cumulative incidence: 14.1%) developed early AMD. After age, smoking, other risk factors, and dietary constituents were adjusted for, a higher mean dietary glycemic index was associated with an increased 10-y risk of early AMD in a comparison of quartiles 1 and 4 [relative risk (RR): 1.77; 95% CI: 1.13, 2.78; P for trend = 0.03]. Conversely, a greater consumption of cereal fiber (RR: 0.68; 95% CI: 0.44, 1.04; P for trend = 0.05) and breads and cereals (predominantly lower glycemic index foods such as oatmeal) (RR: 0.67; 95% CI: 0.44, 1.02; P for trend = 0.03) was associated with a reduced risk of incident early AMD. No relation was observed with late AMD. CONCLUSIONS: A high-glycemic-index diet is a risk factor for early AMD -- the recognized precursor of sight-threatening late AMD. Low-glycemic-index foods such as oatmeal may protect against early AMD.

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Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

October 2008

Volume

88

Issue

4

Start / End Page

1104 / 1110

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Risk Factors
  • Prospective Studies
  • Nutrition & Dietetics
  • New South Wales
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
 

Citation

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Kaushik, S., Wang, J. J., Flood, V., Tan, J. S. L., Barclay, A. W., Wong, T. Y., … Mitchell, P. (2008). Dietary glycemic index and the risk of age-related macular degeneration. Am J Clin Nutr, 88(4), 1104–1110. https://doi.org/10.1093/ajcn/88.4.1104
Kaushik, Shweta, Jie Jin Wang, Victoria Flood, Jennifer Sue Ling Tan, Alan W. Barclay, Tien Y. Wong, Jennie Brand-Miller, and Paul Mitchell. “Dietary glycemic index and the risk of age-related macular degeneration.Am J Clin Nutr 88, no. 4 (October 2008): 1104–10. https://doi.org/10.1093/ajcn/88.4.1104.
Kaushik S, Wang JJ, Flood V, Tan JSL, Barclay AW, Wong TY, et al. Dietary glycemic index and the risk of age-related macular degeneration. Am J Clin Nutr. 2008 Oct;88(4):1104–10.
Kaushik, Shweta, et al. “Dietary glycemic index and the risk of age-related macular degeneration.Am J Clin Nutr, vol. 88, no. 4, Oct. 2008, pp. 1104–10. Pubmed, doi:10.1093/ajcn/88.4.1104.
Kaushik S, Wang JJ, Flood V, Tan JSL, Barclay AW, Wong TY, Brand-Miller J, Mitchell P. Dietary glycemic index and the risk of age-related macular degeneration. Am J Clin Nutr. 2008 Oct;88(4):1104–1110.
Journal cover image

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

October 2008

Volume

88

Issue

4

Start / End Page

1104 / 1110

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Risk Factors
  • Prospective Studies
  • Nutrition & Dietetics
  • New South Wales
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence