Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA).

Journal Article (Journal Article)

OBJECTIVE: To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy. RESULTS: After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident. CONCLUSION: The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.

Full Text

Duke Authors

Cited Authors

  • Kreis, AJ; Wong, TY; Islam, FMA; Klein, R; Klein, BEK; Cotch, MF; Jenkins, AJ; Shea, S; Wang, JJ

Published Date

  • January 2009

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 40 - 42

PubMed ID

  • 19156628

Pubmed Central ID

  • PMC2757060

Electronic International Standard Serial Number (EISSN)

  • 1752-8984

Digital Object Identifier (DOI)

  • 10.3132/dvdr.2009.008


  • eng

Conference Location

  • England