Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA).
OBJECTIVE: To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy. RESULTS: After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident. CONCLUSION: The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.
Duke Scholars
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Triglycerides
- Reproducibility of Results
- Magnetic Resonance Spectroscopy
- Lipoproteins, VLDL
- Lipoproteins, LDL
- Lipoproteins, HDL
- Lipoproteins
- Humans
- Ethnicity
- Endocrinology & Metabolism
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Triglycerides
- Reproducibility of Results
- Magnetic Resonance Spectroscopy
- Lipoproteins, VLDL
- Lipoproteins, LDL
- Lipoproteins, HDL
- Lipoproteins
- Humans
- Ethnicity
- Endocrinology & Metabolism