Retinal arteriolar caliber predicts incident retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.

Published

Journal Article

Changes in retinal vascular caliber may reflect subclinical microvascular disease and provide prognostic information regarding risk of retinopathy. In this study, we examined the prospective association of retinal vascular caliber with retinopathy risk in an Australian population-based cohort. A total of 906 participants without retinopathy at baseline had retinal vascular caliber measured from photographs and were followed-up for 5 years for incident retinopathy. After adjusting for age, sex, systolic blood pressure, A1C, and other risk factors, individuals with wider retinal arteriolar caliber (widest 25% vs. the remaining three-quarters of the population) were more likely to develop incident retinopathy (odds ratio 4.79 [95% CI 1.57-14.58]). This association was not significant in individuals without diabetes. Venular caliber did not predict incident retinopathy. Our findings suggest that retinal arteriolar dilatation is a specific sign of diabetic microvascular dysfunction and may be a preclinical marker of diabetic retinopathy.

Full Text

Duke Authors

Cited Authors

  • Rogers, SL; Tikellis, G; Cheung, N; Tapp, R; Shaw, J; Zimmet, PZ; Mitchell, P; Wang, JJ; Wong, TY

Published Date

  • April 2008

Published In

Volume / Issue

  • 31 / 4

Start / End Page

  • 761 - 763

PubMed ID

  • 18184895

Pubmed Central ID

  • 18184895

Electronic International Standard Serial Number (EISSN)

  • 1935-5548

Digital Object Identifier (DOI)

  • 10.2337/dc07-1622

Language

  • eng

Conference Location

  • United States