FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.

Journal Article (Journal Article)

OBJECTIVE: Association between genetic variants at the FTO locus and obesity has been consistently observed in populations of European ancestry and inconsistently in non-Europeans. The aim of this study was to examine the effects of FTO variants on obesity and type 2 diabetes in Southeast Asian populations. RESEARCH DESIGN AND METHODS: We examined associations between nine previously reported FTO single nucleotide polymorphisms (SNPs) with obesity, type 2 diabetes, and related traits in 4,298 participants (2,919 Chinese, 785 Malays, and 594 Asian Indians) from the 1998 Singapore National Health Survey (NHS98) and 2,996 Malays from the Singapore Malay Eye Study (SiMES). RESULTS: All nine SNPs exhibited strong linkage disequilibrium (r(2) = 0.6-0.99), and minor alleles were associated with obesity in the same direction as previous studies with effect sizes ranging from 0.42 to 0.68 kg/m(2) (P < 0.0001) in NHS98 Chinese, 0.65 to 0.91 kg/m(2) (P < 0.02) in NHS98 Malays, and 0.52 to 0.64 kg/m(2) (P < 0.0001) in SiMES Malays after adjustment for age, sex, smoking, alcohol consumption, and exercise. The variants were also associated with type 2 diabetes, though not after adjustment for BMI (with the exception of the SiMES Malays: odds ratio 1.17-1.22; P

Full Text

Duke Authors

Cited Authors

  • Tan, JT; Dorajoo, R; Seielstad, M; Sim, XL; Ong, RT-H; Chia, KS; Wong, TY; Saw, SM; Chew, SK; Aung, T; Tai, E-S

Published Date

  • October 2008

Published In

Volume / Issue

  • 57 / 10

Start / End Page

  • 2851 - 2857

PubMed ID

  • 18599522

Pubmed Central ID

  • PMC2551698

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

Digital Object Identifier (DOI)

  • 10.2337/db08-0214


  • eng

Conference Location

  • United States