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Diabetic retinopathy and systemic vascular complications.

Publication ,  Journal Article
Cheung, N; Wong, TY
Published in: Prog Retin Eye Res
March 2008

Retinopathy is the most common complication of diabetes. The assessment of retinopathy signs presents clinicians a unique opportunity to directly visualize and assess the actual morphology of diabetic microvascular damage. Extensive studies have now shown that people with diabetic retinopathy have excess risks of systemic vascular complications, including subclinical and clinical stroke, coronary heart disease, heart failure, and nephropathy. There is also emerging evidence to suggest that diabetic retinopathy may share common genetic linkages with systemic vascular complications. The extant literature, therefore, supports the theory that diabetic retinopathy reflects widespread microcirculatory disease not only in the eye but also vital organs elsewhere in the body. Being a uniquely specific and non-invasively assessable measure of diabetic microvascular damage, retinopathy may also be envisioned as a novel biomarker of vascular disease risk in asymptomatic patients with diabetes. This review summarizes recent studies on the systemic associations of diabetic retinopathy, and discusses their pathophysiological significance and clinical implications.

Duke Scholars

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Published In

Prog Retin Eye Res

DOI

ISSN

1350-9462

Publication Date

March 2008

Volume

27

Issue

2

Start / End Page

161 / 176

Location

England

Related Subject Headings

  • Vascular Diseases
  • Ophthalmology & Optometry
  • Humans
  • Diabetic Retinopathy
  • Animals
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

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Cheung, N., & Wong, T. Y. (2008). Diabetic retinopathy and systemic vascular complications. Prog Retin Eye Res, 27(2), 161–176. https://doi.org/10.1016/j.preteyeres.2007.12.001
Cheung, Ning, and Tien Y. Wong. “Diabetic retinopathy and systemic vascular complications.Prog Retin Eye Res 27, no. 2 (March 2008): 161–76. https://doi.org/10.1016/j.preteyeres.2007.12.001.
Cheung N, Wong TY. Diabetic retinopathy and systemic vascular complications. Prog Retin Eye Res. 2008 Mar;27(2):161–76.
Cheung, Ning, and Tien Y. Wong. “Diabetic retinopathy and systemic vascular complications.Prog Retin Eye Res, vol. 27, no. 2, Mar. 2008, pp. 161–76. Pubmed, doi:10.1016/j.preteyeres.2007.12.001.
Cheung N, Wong TY. Diabetic retinopathy and systemic vascular complications. Prog Retin Eye Res. 2008 Mar;27(2):161–176.
Journal cover image

Published In

Prog Retin Eye Res

DOI

ISSN

1350-9462

Publication Date

March 2008

Volume

27

Issue

2

Start / End Page

161 / 176

Location

England

Related Subject Headings

  • Vascular Diseases
  • Ophthalmology & Optometry
  • Humans
  • Diabetic Retinopathy
  • Animals
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry