Ex-vivo liver perfusion for organ preservation: Recent advances in the field.

Journal Article (Journal Article;Review)

Liver transplantation is the optimal treatment for end-stage liver disease but is limited by the severe shortage of donor organs. This shortage has prompted increased utilization of marginal grafts from DCD and extended criteria donors, which poorly tolerate cold storage in comparison to standard criteria grafts. Ex-vivo liver perfusion (EVLP) technology has emerged as a potential alternative to cold storage for organ preservation, but there is no consensus regarding the optimal temperature or conditions for EVLP. Herein, we review recent advances in both pre-clinical and clinical studies, organized by perfusion temperature (hypothermic, subnormothermic, normothermic).

Full Text

Duke Authors

Cited Authors

  • Barbas, AS; Goldaracena, N; Dib, MJ; Selzner, M

Published Date

  • July 2016

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 154 - 160

PubMed ID

  • 27158081

Pubmed Central ID

  • 27158081

Electronic International Standard Serial Number (EISSN)

  • 1557-9816

Digital Object Identifier (DOI)

  • 10.1016/j.trre.2016.03.002

Language

  • eng

Conference Location

  • United States