Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.


Journal Article

Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.

Full Text

Duke Authors

Cited Authors

  • Kaslow, RA; Carrington, M; Apple, R; Park, L; Muñoz, A; Saah, AJ; Goedert, JJ; Winkler, C; O'Brien, SJ; Rinaldo, C; Detels, R; Blattner, W; Phair, J; Erlich, H; Mann, DL

Published Date

  • April 1996

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 405 - 411

PubMed ID

  • 8597949

Pubmed Central ID

  • 8597949

International Standard Serial Number (ISSN)

  • 1078-8956


  • eng

Conference Location

  • United States