Effect of smoking on the clinical progression of HIV-1 infection.

Journal Article (Journal Article;Multicenter Study)

Cigarette smoking as a risk factor in progression of HIV-1 disease was investigated in the Multicenter AIDS Cohort Study of homosexual men. Longitudinal data for T-cell subsets, HIV-related clinical symptoms, smoking behavior, and AIDS medication use were collected semiannually from 2,499 HIV-1-seropositive men for up to 9 years. Survival methods, including Kaplan-Meier analysis and multivariate Cox regression models, were used to assess the effect of cigarette smoking on development of Pneumocystis carinii pneumonia (PCP), AIDS, death, and self-reported oral thrush. After adjustment for CD4+ lymphocyte count and use of antiretroviral and anti-PCP medications, smoking was not significantly associated with progression to PCP, AIDS, or death in either the HIV-seroprevalent or-seroincident cohort members. Among men who had baseline CD4+ cell counts > 200/microliter, smoking was associated with a 40% increase in the hazard of oral thrush (p < or = 0.01). These data indicate that cigarette smoking does not have a major effect on the progression of HIV-1 infection to AIDS or death but may affect the incidence of oral thrush.

Full Text

Duke Authors

Cited Authors

  • Galai, N; Park, LP; Wesch, J; Visscher, B; Riddler, S; Margolick, JB

Published Date

  • April 15, 1997

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • 451 - 458

PubMed ID

  • 9170420

International Standard Serial Number (ISSN)

  • 1077-9450

Digital Object Identifier (DOI)

  • 10.1097/00042560-199704150-00009


  • eng

Conference Location

  • United States