Tristetraprolin as a Therapeutic Target in Inflammatory Disease.

Journal Article (Journal Article;Review)

Members of the tristetraprolin (TTP) family of RNA-binding proteins are found in all major eukaryotic groups. TTP family members, from plants through humans, can bind adenosine-uridine rich elements in target mRNAs with high affinity. In mammalian cells, these proteins then promote deadenylation and decay of target transcripts. Four such proteins are found in mice, of which the best studied is TTP. When the gene encoding TTP is disrupted in mice, the animals develop a severe syndrome of arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia. Conversely, recent overexpression studies have demonstrated protection against several experimental models of immune inflammatory disease. This endogenous anti-inflammatory protein could serve as the basis for novel approaches to therapy of similar conditions in humans.

Full Text

Duke Authors

Cited Authors

  • Patial, S; Blackshear, PJ

Published Date

  • October 2016

Published In

Volume / Issue

  • 37 / 10

Start / End Page

  • 811 - 821

PubMed ID

  • 27503556

Pubmed Central ID

  • PMC5030171

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2016.07.002

Language

  • eng

Conference Location

  • England