The Changing Landscape of Randomized Clinical Trials in Cardiovascular Disease.

Journal Article (Review)

Large randomized clinical trials in cardiovascular disease have proliferated over the past 3 decades, with results that have influenced every aspect of cardiology practice. Despite these advances, there remains a substantial need for more high-quality evidence to inform cardiovascular clinical practice, given the increasing prevalence of cardiovascular disease around the world. Traditional clinical trials are increasingly challenging due to rising costs, increasing complexity and length, and burdensome institutional and regulatory requirements. This review will examine the current landscape of cardiovascular clinical trials in the United States, highlight recently conducted registry-based clinical trials, and discuss the potential attributes of the recently launched pragmatic clinical trial by the Patient-Centered Outcomes Research Institute's National Patient-Centered Clinical Research Network, called the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing the Benefits and Long-term Effectiveness) trial.

Full Text

Duke Authors

Cited Authors

  • Jones, WS; Roe, MT; Antman, EM; Pletcher, MJ; Harrington, RA; Rothman, RL; Oetgen, WJ; Rao, SV; Krucoff, MW; Curtis, LH; Hernandez, AF; Masoudi, FA

Published Date

  • October 2016

Published In

Volume / Issue

  • 68 / 17

Start / End Page

  • 1898 - 1907

PubMed ID

  • 27765193

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

International Standard Serial Number (ISSN)

  • 0735-1097

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2016.07.781


  • eng