Joint Inference for Competing Risks Survival Data.

Published

Journal Article

This article develops joint inferential methods for the cause-specific hazard function and the cumulative incidence function of a specific type of failure to assess the effects of a variable on the time to the type of failure of interest in the presence of competing risks. Joint inference for the two functions are needed in practice because (i) they describe different characteristics of a given type of failure, (ii) they do not uniquely determine each other, and (iii) the effects of a variable on the two functions can be different and one often does not know which effects are to be expected. We study both the group comparison problem and the regression problem. We also discuss joint inference for other related functions. Our simulation shows that our joint tests can be considerably more powerful than the Bonferroni method, which has important practical implications to the analysis and design of clinical studies with competing risks data. We illustrate our method using a Hodgkin disease data and a lymphoma data. Supplementary materials for this article are available online.

Full Text

Duke Authors

Cited Authors

  • Li, G; Yang, Q

Published Date

  • January 2016

Published In

Volume / Issue

  • 111 / 515

Start / End Page

  • 1289 - 1300

PubMed ID

  • 31745375

Pubmed Central ID

  • 31745375

Electronic International Standard Serial Number (EISSN)

  • 1537-274X

International Standard Serial Number (ISSN)

  • 0162-1459

Digital Object Identifier (DOI)

  • 10.1080/01621459.2015.1093942

Language

  • eng