Tissue engineering strategies designed to realize the endogenous regenerative potential of peripheral nerves


Journal Article (Review)

Bridging peripheral nerve gaps without the use of autografts has significant clinical importance. But in order to rationally design novel scaffolds, a good understanding of the nerve regeneration process is vital. Appropriate amount of structurai and chemical cues are required to stimulate the endogenous mechanisms of repair and functional recovery. Synthetic and natural materials present various opportunities to induce the growth of supporting cells as well as promote axon regeneration. An overview of tissue engineering strategies currently being explored that stimulate the different steps of the regenerative sequence is presented. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA.

Full Text

Duke Authors

Cited Authors

  • Mukhatyar, V; Karumbaiah, L; Yeh, J; Bellamkonda, R

Published Date

  • December 11, 2009

Published In

Volume / Issue

  • 21 / 46

Start / End Page

  • 4670 - 4679

International Standard Serial Number (ISSN)

  • 0935-9648

Digital Object Identifier (DOI)

  • 10.1002/adma.200900746

Citation Source

  • Scopus