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Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.

Publication ,  Journal Article
Salehi, M; D'Alessio, DA
Published in: Surg Obes Relat Dis
July 2016

Bariatric surgery is the most effective treatment for obesity and diabetes. The 2 most commonly performed weight-loss procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy, improve glycemic control in patients with type 2 diabetes independent of weight loss. One of the early hypotheses raised to explain the immediate antidiabetic effect of RYGB was that rapid delivery of nutrients from the stomach pouch into the distal small intestine enhances enteroinsular signaling to promote insulin signaling. Given the tenfold increase in postmeal glucagon-like peptide-1 (GLP-1) response compared to unchanged integrated levels of postprandial glucose-dependent insulinotropic peptide after RYGB, enhanced meal-induced insulin secretion after this procedure was thought to be the result of elevated glucose and GLP-1 levels. In this contribution to the larger point-counterpoint debate about the role of GLP-1 after bariatric surgery, most of the focus will be on RYGB.

Duke Scholars

Published In

Surg Obes Relat Dis

DOI

EISSN

1878-7533

Publication Date

July 2016

Volume

12

Issue

6

Start / End Page

1230 / 1235

Location

United States

Related Subject Headings

  • Weight Loss
  • Surgery
  • Postprandial Period
  • Peptide Fragments
  • Insulin Secretion
  • Insulin
  • Hypoglycemia
  • Hyperinsulinism
  • Humans
  • Glucagon-Like Peptide 1
 

Citation

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ICMJE
MLA
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Salehi, M., & D’Alessio, D. A. (2016). Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe. Surg Obes Relat Dis, 12(6), 1230–1235. https://doi.org/10.1016/j.soard.2016.05.008
Salehi, Marzieh, and David A. D’Alessio. “Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.Surg Obes Relat Dis 12, no. 6 (July 2016): 1230–35. https://doi.org/10.1016/j.soard.2016.05.008.
Salehi M, D’Alessio DA. Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe. Surg Obes Relat Dis. 2016 Jul;12(6):1230–5.
Salehi, Marzieh, and David A. D’Alessio. “Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.Surg Obes Relat Dis, vol. 12, no. 6, July 2016, pp. 1230–35. Pubmed, doi:10.1016/j.soard.2016.05.008.
Salehi M, D’Alessio DA. Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe. Surg Obes Relat Dis. 2016 Jul;12(6):1230–1235.
Journal cover image

Published In

Surg Obes Relat Dis

DOI

EISSN

1878-7533

Publication Date

July 2016

Volume

12

Issue

6

Start / End Page

1230 / 1235

Location

United States

Related Subject Headings

  • Weight Loss
  • Surgery
  • Postprandial Period
  • Peptide Fragments
  • Insulin Secretion
  • Insulin
  • Hypoglycemia
  • Hyperinsulinism
  • Humans
  • Glucagon-Like Peptide 1