Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.

Journal Article (Journal Article;Review)

Bariatric surgery is the most effective treatment for obesity and diabetes. The 2 most commonly performed weight-loss procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy, improve glycemic control in patients with type 2 diabetes independent of weight loss. One of the early hypotheses raised to explain the immediate antidiabetic effect of RYGB was that rapid delivery of nutrients from the stomach pouch into the distal small intestine enhances enteroinsular signaling to promote insulin signaling. Given the tenfold increase in postmeal glucagon-like peptide-1 (GLP-1) response compared to unchanged integrated levels of postprandial glucose-dependent insulinotropic peptide after RYGB, enhanced meal-induced insulin secretion after this procedure was thought to be the result of elevated glucose and GLP-1 levels. In this contribution to the larger point-counterpoint debate about the role of GLP-1 after bariatric surgery, most of the focus will be on RYGB.

Full Text

Duke Authors

Cited Authors

  • Salehi, M; D'Alessio, DA

Published Date

  • July 2016

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 1230 - 1235

PubMed ID

  • 27568473

Pubmed Central ID

  • PMC5002889

Electronic International Standard Serial Number (EISSN)

  • 1878-7533

Digital Object Identifier (DOI)

  • 10.1016/j.soard.2016.05.008


  • eng

Conference Location

  • United States