Skip to main content
Journal cover image

Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome.

Publication ,  Journal Article
Patel, A; Hasak, S; Cassell, B; Ciorba, MA; Vivio, EE; Kumar, M; Gyawali, CP; Sayuk, GS
Published in: Aliment Pharmacol Ther
August 2016

BACKGROUND: Sleep disturbances are common, and perhaps are even more prevalent in irritable bowel syndrome (IBS). AIMS: To determine the effect of measured sleep on IBS symptoms the following day, IBS-specific quality of life (IBS-QOL) and non-GI pain symptoms. METHODS: IBS patients' sleep patterns were compared to healthy individuals via wrist-mounted actigraphy over 7 days. Daily bowel pain logs (severity, distress; 10-point Likert) stool pattern (Bristol scale) and supporting symptoms (e.g. bloating, urgency; 5-point Likert) were kept. Validated measures, including the GI Symptom Rating Scale-IBS, Visceral Sensitivity Index, Pittsburgh Sleep Quality Index and the IBS-Quality of Life were collected. Mediation analysis explored the relationship between sleep, mood and bowel symptoms. RESULTS: Fifty subjects (38.6 ± 1.0 years old, 44 female; 24 IBS and 26 healthy controls) completed sleep monitoring. IBS patients slept more hours per day (7.7 ± 0.2 vs. 7.1 ± 0.1, P = 0.008), but felt less well-rested. IBS patients demonstrated more waking episodes during sleep (waking episodes; 12.1 vs. 9.3, P < 0.001). Waking episodes predicted worse abdominal pain (P ≤ 0.01) and GI distress (P < 0.001), but not bowel pattern or accessory IBS symptoms (P > 0.3 for each). Waking episodes negatively correlated with general- and IBS-specific QOL in IBS (r = -0.58 and -0.52, P < 0.001 for each). Disturbed sleep effects on abdominal pain were partially explained by mood as an intermediate. CONCLUSIONS: Sleep disturbances are more common in irritable bowel syndrome, and correlate with IBS-related pain, distress and poorer irritable bowel syndrome-related quality of life. Disturbed sleep effects extend beyond the bowel, leading to worse mood and greater somatic pain in patients with the irritable bowel syndrome.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Aliment Pharmacol Ther

DOI

EISSN

1365-2036

Publication Date

August 2016

Volume

44

Issue

3

Start / End Page

246 / 258

Location

England

Related Subject Headings

  • Young Adult
  • Sleep Wake Disorders
  • Sleep
  • Quality of Life
  • Nociceptive Pain
  • Mood Disorders
  • Middle Aged
  • Male
  • Irritable Bowel Syndrome
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, A., Hasak, S., Cassell, B., Ciorba, M. A., Vivio, E. E., Kumar, M., … Sayuk, G. S. (2016). Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome. Aliment Pharmacol Ther, 44(3), 246–258. https://doi.org/10.1111/apt.13677
Patel, A., S. Hasak, B. Cassell, M. A. Ciorba, E. E. Vivio, M. Kumar, C Prakash Gyawali, and G. S. Sayuk. “Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome.Aliment Pharmacol Ther 44, no. 3 (August 2016): 246–58. https://doi.org/10.1111/apt.13677.
Patel A, Hasak S, Cassell B, Ciorba MA, Vivio EE, Kumar M, et al. Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome. Aliment Pharmacol Ther. 2016 Aug;44(3):246–58.
Patel, A., et al. “Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome.Aliment Pharmacol Ther, vol. 44, no. 3, Aug. 2016, pp. 246–58. Pubmed, doi:10.1111/apt.13677.
Patel A, Hasak S, Cassell B, Ciorba MA, Vivio EE, Kumar M, Gyawali CP, Sayuk GS. Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome. Aliment Pharmacol Ther. 2016 Aug;44(3):246–258.
Journal cover image

Published In

Aliment Pharmacol Ther

DOI

EISSN

1365-2036

Publication Date

August 2016

Volume

44

Issue

3

Start / End Page

246 / 258

Location

England

Related Subject Headings

  • Young Adult
  • Sleep Wake Disorders
  • Sleep
  • Quality of Life
  • Nociceptive Pain
  • Mood Disorders
  • Middle Aged
  • Male
  • Irritable Bowel Syndrome
  • Humans