The epidemiology, evaluation and treatment of stroke in adults with sickle cell disease.

Journal Article (Journal Article;Review)

Stroke is a frequent and severe complication in adults with sickle cell disease. Ischemic stroke often causes physical and cognitive disability, while hemorrhagic stroke has a high mortality rate. As more children survive, the number of strokes in adults is increasing, yet stroke remains poorly understood. We review the epidemiology of ischemic and hemorrhagic stroke in adults with sickle cell disease and outline a practical approach to the evaluation of stroke including both sickle cell disease specific and general risk factors. We discuss the acute treatment and secondary prevention of stroke in this population based on the evidence in children with sickle cell disease and the general population, in addition to the limited studies in adults with sickle cell disease.

Full Text

Duke Authors

Cited Authors

  • Strouse, JJ; Lanzkron, S; Urrutia, V

Published Date

  • December 2011

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 597 - 606

PubMed ID

  • 22077524

Pubmed Central ID

  • PMC3267235

Electronic International Standard Serial Number (EISSN)

  • 1747-4094

Digital Object Identifier (DOI)

  • 10.1586/ehm.11.61


  • eng

Conference Location

  • England