Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair.

Published

Journal Article

Cleft lip and palate can be associated with coagulopathy. Here, we report the first known case of congenital platelet disorder and von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. After identifying the underlying pathology, platelet infusions and aminocaproic acid were given to decrease bleeding from a second surgical procedure. Whole exome sequencing identified a von Willebrand factor gene mutation, an adenine to guanine substitution at the c.475A location. A high index of suspicion should be had for coagulopathy in patients with syndromic cleft lip and palate.

Full Text

Duke Authors

Cited Authors

  • Pang, J; Zelken, J; Dorafshar, AH; Strouse, JJ; Redett, R

Published Date

  • November 2014

Published In

Volume / Issue

  • 51 / 6

Start / End Page

  • 740 - 742

PubMed ID

  • 24237226

Pubmed Central ID

  • 24237226

Electronic International Standard Serial Number (EISSN)

  • 1545-1569

International Standard Serial Number (ISSN)

  • 1055-6656

Digital Object Identifier (DOI)

  • 10.1597/13-186

Language

  • eng