Congenital platelet disorder and type I von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair.
Journal Article (Journal Article)
Cleft lip and palate can be associated with coagulopathy. Here, we report the first known case of congenital platelet disorder and von Willebrand disease presenting as prolonged bleeding after cleft lip and palate repair. After identifying the underlying pathology, platelet infusions and aminocaproic acid were given to decrease bleeding from a second surgical procedure. Whole exome sequencing identified a von Willebrand factor gene mutation, an adenine to guanine substitution at the c.475A location. A high index of suspicion should be had for coagulopathy in patients with syndromic cleft lip and palate.
Full Text
Duke Authors
Cited Authors
- Pang, J; Zelken, J; Dorafshar, AH; Strouse, JJ; Redett, R
Published Date
- November 2014
Published In
Volume / Issue
- 51 / 6
Start / End Page
- 740 - 742
PubMed ID
- 24237226
Electronic International Standard Serial Number (EISSN)
- 1545-1569
Digital Object Identifier (DOI)
- 10.1597/13-186
Language
- eng
Conference Location
- United States