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Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA).

Publication ,  Journal Article
Strouse, JJ; Cox, CS; Melhem, ER; Lu, H; Kraut, MA; Razumovsky, A; Yohay, K; van Zijl, PC; Casella, JF
Published in: Blood
July 1, 2006

Overt stroke, clinically "silent" cerebral infarct, and neurocognitive impairment are frequent complications of sickle cell anemia (SCA). Current imaging techniques have limited sensitivity and specificity to identify children at risk for neurocognitive impairment. We prospectively evaluated 24 children with SCA with a neurologic exam, complete blood count, transcranial Doppler ultrasound (TCD), measurement of intelligence quotient (IQ), and magnetic resonance imaging (MRI) with measurement of cerebral blood flow (CBF) using continuous arterial spin-labeling (CASL) MRI. Average CBF to gray matter was 112 +/- 36 mL/100 g/min. We identified a strong inverse relationship between performance IQ and CBF (-1.5 points per 10 mL/100 g/min increase in CBF, P = .013). Elevated steady-state white blood cell count (> or = 14 x 10(9)/L [14,000/microL]) was associated with lower full scale IQ (86 +/- 9 vs 99 +/- 10, P = .005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD.

Duke Scholars

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

July 1, 2006

Volume

108

Issue

1

Start / End Page

379 / 381

Location

United States

Related Subject Headings

  • Spin Labels
  • Sensitivity and Specificity
  • Prospective Studies
  • Neuropsychological Tests
  • Magnetic Resonance Imaging
  • Linear Models
  • Immunology
  • Humans
  • Follow-Up Studies
  • Data Interpretation, Statistical
 

Citation

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MLA
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Strouse, J. J., Cox, C. S., Melhem, E. R., Lu, H., Kraut, M. A., Razumovsky, A., … Casella, J. F. (2006). Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). Blood, 108(1), 379–381. https://doi.org/10.1182/blood-2005-10-4029
Strouse, John J., Christiane S. Cox, Elias R. Melhem, Hanzhang Lu, Michael A. Kraut, Alexander Razumovsky, Kaleb Yohay, Peter C. van Zijl, and James F. Casella. “Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA).Blood 108, no. 1 (July 1, 2006): 379–81. https://doi.org/10.1182/blood-2005-10-4029.
Strouse, John J., et al. “Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA).Blood, vol. 108, no. 1, July 2006, pp. 379–81. Pubmed, doi:10.1182/blood-2005-10-4029.
Strouse JJ, Cox CS, Melhem ER, Lu H, Kraut MA, Razumovsky A, Yohay K, van Zijl PC, Casella JF. Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). Blood. 2006 Jul 1;108(1):379–381.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

July 1, 2006

Volume

108

Issue

1

Start / End Page

379 / 381

Location

United States

Related Subject Headings

  • Spin Labels
  • Sensitivity and Specificity
  • Prospective Studies
  • Neuropsychological Tests
  • Magnetic Resonance Imaging
  • Linear Models
  • Immunology
  • Humans
  • Follow-Up Studies
  • Data Interpretation, Statistical