Incidental findings on brain magnetic resonance imaging of children with sickle cell disease.

Journal Article

We describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial.We included 953 children between 5 and 14 years of age who were screened with MRI of the brain for the Silent Infarct Transfusion Trial. All had sickle cell anemia or sickle beta-null thalassemia. MRI scans were interpreted by 3 neuroradiologists. MRI scans reported to have any abnormality were reviewed by 2 study neuroradiologists. Incidental findings were classified into 4 categories, that is, no, routine, urgent, or immediate referral recommended. Cerebral infarctions and vascular lesions were not considered incidental and were excluded.We identified 63 children (6.6% [95% confidence interval: 5.1%-8.4%]) with 68 incidental intracranial MRI findings. Findings were classified as urgent in 6 cases (0.6%), routine in 25 cases (2.6%), and no referral required in 32 cases (3.4%). No children required immediate referral. Two children with urgent findings underwent surgery in the subsequent 6 months.In this large cohort of children, incidental intracranial findings were identified for 6.6%, with potentially serious or urgent findings for 0.6%.

Full Text

Duke Authors

Cited Authors

  • Jordan, LC; McKinstry, RC; Kraut, MA; Ball, WS; Vendt, BA; Casella, JF; DeBaun, MR; Strouse, JJ; Silent Infarct Transfusion Trial Investigators,

Published Date

  • July 2010

Published In

Volume / Issue

  • 126 / 1

Start / End Page

  • 53 - 61

PubMed ID

  • 20547639

Electronic International Standard Serial Number (EISSN)

  • 1098-4275

International Standard Serial Number (ISSN)

  • 0031-4005

Digital Object Identifier (DOI)

  • 10.1542/peds.2009-2800

Language

  • eng