Emerging Skin T-Cell Functions in Response to Environmental Insults.

Journal Article (Journal Article;Review)

Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.

Full Text

Duke Authors

Cited Authors

  • Suwanpradid, J; Holcomb, ZE; MacLeod, AS

Published Date

  • February 2017

Published In

Volume / Issue

  • 137 / 2

Start / End Page

  • 288 - 294

PubMed ID

  • 27784595

Pubmed Central ID

  • PMC5552043

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

Digital Object Identifier (DOI)

  • 10.1016/j.jid.2016.08.013


  • eng

Conference Location

  • United States