The interplay between neurons and glia in synapse development and plasticity.

Journal Article (Journal Article;Review)

In the brain, the formation of complex neuronal networks amenable to experience-dependent remodeling is complicated by the diversity of neurons and synapse types. The establishment of a functional brain depends not only on neurons, but also non-neuronal glial cells. Glia are in continuous bi-directional communication with neurons to direct the formation and refinement of synaptic connectivity. This article reviews important findings, which uncovered cellular and molecular aspects of the neuron-glia cross-talk that govern the formation and remodeling of synapses and circuits. In vivo evidence demonstrating the critical interplay between neurons and glia will be the major focus. Additional attention will be given to how aberrant communication between neurons and glia may contribute to neural pathologies.

Full Text

Duke Authors

Cited Authors

  • Stogsdill, JA; Eroglu, C

Published Date

  • February 2017

Published In

Volume / Issue

  • 42 /

Start / End Page

  • 1 - 8

PubMed ID

  • 27788368

Pubmed Central ID

  • PMC5316301

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2016.09.016


  • eng

Conference Location

  • England