Pharmacogenomics for personalized pain medicine.

Journal Article (Journal Article;Review)

Pharmacogenomics aims to unravel the way that human genetic variation affects drug efficacy and toxicity. Genome-wide association studies and candidate gene findings suggest that genetic approaches may help choose the most appropriate drug and dosage while preventing adverse drug reactions (ADRs). Pain is an unpleasant feeling that usually results from tissue damage. The management of different types of pain (acute, chronic, inflammatory, neuropathic, or cancer) is challenging. Currently, drug intervention is the first-line therapy for resolving pain. However, differences in drug efficacy between individuals are common with pain medications. Moreover, some patients experience ADRs after being treated with specific pain drugs. This review discusses the use of drugs for pain management in the context of the recent pharmacogenomic studies on ADRs and drug efficacy.

Full Text

Duke Authors

Cited Authors

  • Ko, T-M; Wong, C-S; Wu, J-Y; Chen, Y-T

Published Date

  • March 2016

Published In

Volume / Issue

  • 54 / 1

Start / End Page

  • 24 - 30

PubMed ID

  • 26976339

Electronic International Standard Serial Number (EISSN)

  • 1875-452X

Digital Object Identifier (DOI)

  • 10.1016/j.aat.2016.02.001


  • eng

Conference Location

  • China (Republic : 1949- )