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Pharmacogenomics for personalized pain medicine.

Publication ,  Journal Article
Ko, T-M; Wong, C-S; Wu, J-Y; Chen, Y-T
Published in: Acta Anaesthesiol Taiwan
March 2016

Pharmacogenomics aims to unravel the way that human genetic variation affects drug efficacy and toxicity. Genome-wide association studies and candidate gene findings suggest that genetic approaches may help choose the most appropriate drug and dosage while preventing adverse drug reactions (ADRs). Pain is an unpleasant feeling that usually results from tissue damage. The management of different types of pain (acute, chronic, inflammatory, neuropathic, or cancer) is challenging. Currently, drug intervention is the first-line therapy for resolving pain. However, differences in drug efficacy between individuals are common with pain medications. Moreover, some patients experience ADRs after being treated with specific pain drugs. This review discusses the use of drugs for pain management in the context of the recent pharmacogenomic studies on ADRs and drug efficacy.

Duke Scholars

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Published In

Acta Anaesthesiol Taiwan

DOI

EISSN

1875-452X

Publication Date

March 2016

Volume

54

Issue

1

Start / End Page

24 / 30

Location

China (Republic : 1949- )

Related Subject Headings

  • Receptors, Opioid, mu
  • Precision Medicine
  • Pharmacogenetics
  • Pain
  • Humans
  • Genome-Wide Association Study
  • Drug Interactions
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP2C9
 

Citation

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Ko, T.-M., Wong, C.-S., Wu, J.-Y., & Chen, Y.-T. (2016). Pharmacogenomics for personalized pain medicine. Acta Anaesthesiol Taiwan, 54(1), 24–30. https://doi.org/10.1016/j.aat.2016.02.001
Ko, Tai-Ming, Chih-Shung Wong, Jer-Yuarn Wu, and Yuan-Tsong Chen. “Pharmacogenomics for personalized pain medicine.Acta Anaesthesiol Taiwan 54, no. 1 (March 2016): 24–30. https://doi.org/10.1016/j.aat.2016.02.001.
Ko T-M, Wong C-S, Wu J-Y, Chen Y-T. Pharmacogenomics for personalized pain medicine. Acta Anaesthesiol Taiwan. 2016 Mar;54(1):24–30.
Ko, Tai-Ming, et al. “Pharmacogenomics for personalized pain medicine.Acta Anaesthesiol Taiwan, vol. 54, no. 1, Mar. 2016, pp. 24–30. Pubmed, doi:10.1016/j.aat.2016.02.001.
Ko T-M, Wong C-S, Wu J-Y, Chen Y-T. Pharmacogenomics for personalized pain medicine. Acta Anaesthesiol Taiwan. 2016 Mar;54(1):24–30.

Published In

Acta Anaesthesiol Taiwan

DOI

EISSN

1875-452X

Publication Date

March 2016

Volume

54

Issue

1

Start / End Page

24 / 30

Location

China (Republic : 1949- )

Related Subject Headings

  • Receptors, Opioid, mu
  • Precision Medicine
  • Pharmacogenetics
  • Pain
  • Humans
  • Genome-Wide Association Study
  • Drug Interactions
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP2C9