The effects of the synthetic nocistatin on blood vessel activities

Published

Journal Article

Nocistatin was synthesized by the solid-phase peptide synthesis method. Its effects on rat systemic arterial pressure; rat hindquarter vascular bed resistance; tension of rabbit pectoral, abdominal, femoral aorta muscle strips without endothelium; and nociceptin induced decreases of rat systemic arterial pressure were determined. The results showed that nocistatin can increase the systemic arterial pressure, increase the hindquarter vascular bed resistance and induce the contraction significantly of abdominal, femoral aorta muscle strips without endothelium; it has no significant effect on tension of pectoral aorta muscle strips, it cannot antagonize significantly the decrease of rat systemic arterial pressure induced by nociceptin. These results suggest that nocistatin has some important effects on blood vessel activities.

Full Text

Duke Authors

Cited Authors

  • Chen, Q; Chen, Y; Chen, L; Yang, D; Dong, S; Wang, R

Published Date

  • January 1, 2001

Published In

Volume / Issue

  • 46 / 8

Start / End Page

  • 675 - 678

International Standard Serial Number (ISSN)

  • 1001-6538

Digital Object Identifier (DOI)

  • 10.1007/BF03182834

Citation Source

  • Scopus