Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice
Journal Article (Journal Article)
AIM: To investigate the effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 or endomorphin-2 analgesia in mice. METHODS: Nocistatin and nocistatin (10-17) were synthesized by solid-phase peptide synthesis method. The mouse tail-flick test was used to assess the pain threshold of the mice and observe the effects of nocistatin and nocistatin (10-17). RESULTS: Nociceptin was shown to antagonize endomorphin-1 and endomorphin-2 analgesia. Nocistatin or nocistatin (10-17) produced no significant effect on basic pain threshold; however, both of them were found to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia. CONCLUSION: Nocistatin and nocistatin (10-17) were shown to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia at supraspinal level.
Full Text
Duke Authors
Cited Authors
- Chen, LX; Chen, Y; Peng, YL; Wang, ZZ; Chen, Q; Wang, R
Published Date
- November 1, 2002
Published In
Volume / Issue
- 37 / 11
Start / End Page
- 837 - 840
International Standard Serial Number (ISSN)
- 0513-4870
Citation Source
- Scopus