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Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice

Publication ,  Journal Article
Chen, LX; Chen, Y; Peng, YL; Wang, ZZ; Chen, Q; Wang, R
Published in: Yaoxue Xuebao
November 1, 2002

AIM: To investigate the effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 or endomorphin-2 analgesia in mice. METHODS: Nocistatin and nocistatin (10-17) were synthesized by solid-phase peptide synthesis method. The mouse tail-flick test was used to assess the pain threshold of the mice and observe the effects of nocistatin and nocistatin (10-17). RESULTS: Nociceptin was shown to antagonize endomorphin-1 and endomorphin-2 analgesia. Nocistatin or nocistatin (10-17) produced no significant effect on basic pain threshold; however, both of them were found to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia. CONCLUSION: Nocistatin and nocistatin (10-17) were shown to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia at supraspinal level.

Duke Scholars

Published In

Yaoxue Xuebao

ISSN

0513-4870

Publication Date

November 1, 2002

Volume

37

Issue

11

Start / End Page

837 / 840

Related Subject Headings

  • Pharmacology & Pharmacy
 

Citation

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Chen, L. X., Chen, Y., Peng, Y. L., Wang, Z. Z., Chen, Q., & Wang, R. (2002). Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice. Yaoxue Xuebao, 37(11), 837–840.
Chen, L. X., Y. Chen, Y. L. Peng, Z. Z. Wang, Q. Chen, and R. Wang. “Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice.” Yaoxue Xuebao 37, no. 11 (November 1, 2002): 837–40.
Chen LX, Chen Y, Peng YL, Wang ZZ, Chen Q, Wang R. Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice. Yaoxue Xuebao. 2002 Nov 1;37(11):837–40.
Chen, L. X., et al. “Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice.” Yaoxue Xuebao, vol. 37, no. 11, Nov. 2002, pp. 837–40.
Chen LX, Chen Y, Peng YL, Wang ZZ, Chen Q, Wang R. Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice. Yaoxue Xuebao. 2002 Nov 1;37(11):837–840.

Published In

Yaoxue Xuebao

ISSN

0513-4870

Publication Date

November 1, 2002

Volume

37

Issue

11

Start / End Page

837 / 840

Related Subject Headings

  • Pharmacology & Pharmacy