[Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat.

Journal Article (Journal Article)

The purpose of this study was to investigate the effects of [Nphe1]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe1]nociceptin(1-13)-NH2 (1.5-12 nmol/kg and 5-120 nmol/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol/kg, respectively) on MAP and HR. Furthermore, [Nphe1]nociceptin(1-13)-NH2 (5-120 nmol/kg) could reverse nociceptin (30 nmol/kg)-induced decrease of HVBR. However, [Nphe1]nociceptin(1-13)-NH2 had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe1]nociceptin(1-13)-NH2 acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.

Full Text

Duke Authors

Cited Authors

  • Chen, Y; Chang, M; Wang, ZZ; Chen, LX; Yang, Q; Qi, YM; Wang, R

Published Date

  • January 2002

Published In

Volume / Issue

  • 80 / 1

Start / End Page

  • 31 - 35

PubMed ID

  • 11911223

International Standard Serial Number (ISSN)

  • 0008-4212

Digital Object Identifier (DOI)

  • 10.1139/y02-003


  • eng

Conference Location

  • Canada