A new wave in treatment of vascular occlusive disease: biodegradable stents--clinical experience and scientific principles.

Journal Article (Journal Article;Review)

Stent-based therapies in percutaneous vascular intervention are associated with significant long-term complications related to in-stent restenosis. A growing body of literature demonstrates the feasibility of biodegradable materials for endovascular stents, which may, in theory, circumvent many of the immunologic and inflammatory response issues seen with long-term metallic stent failure in coronary and peripheral applications. This review describes the history of endovascular stents and the challenges encountered with metallic, drug-eluting, and biodegradable stents. A review of the basic engineering principles of biodegradable stents is provided, along with a discussion of the cellular mechanisms of restenosis.

Full Text

Duke Authors

Cited Authors

  • Brown, DA; Lee, EW; Loh, CT; Kee, ST

Published Date

  • March 2009

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 315 - 324

PubMed ID

  • 19157901

Electronic International Standard Serial Number (EISSN)

  • 1535-7732

Digital Object Identifier (DOI)

  • 10.1016/j.jvir.2008.11.007


  • eng

Conference Location

  • United States