African-American heredity prostate cancer study: a model for genetic research.

Journal Article (Journal Article)

A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.

Full Text

Duke Authors

Cited Authors

  • Powell, IJ; Carpten, J; Dunston, G; Kittles, R; Bennett, J; Hoke, G; Pettaway, C; Weinrich, S; Vijayakumar, S; Ahaghotu, CA; Boykin, W; Mason, T; Royal, C; Baffoe-Bonnie, A; Bailey-Wilson, J; Berg, K; Trent, J; Collins, F

Published Date

  • April 2001

Published In

Volume / Issue

  • 93 / 4

Start / End Page

  • 120 - 123

PubMed ID

  • 12653398

Pubmed Central ID

  • PMC2593987

Electronic International Standard Serial Number (EISSN)

  • 1943-4693

International Standard Serial Number (ISSN)

  • 0027-9684


  • eng