Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).


Journal Article

BACKGROUND: The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected. METHODS: We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS: Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS: These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

Full Text

Duke Authors

Cited Authors

  • Baffoe-Bonnie, AB; Kittles, RA; Gillanders, E; Ou, L; George, A; Robbins, C; Ahaghotu, C; Bennett, J; Boykin, W; Hoke, G; Mason, T; Pettaway, C; Vijayakumar, S; Weinrich, S; Jones, MP; Gildea, D; Riedesel, E; Albertus, J; Moses, T; Lockwood, E; Klaric, M; Faruque, M; Royal, C; Trent, JM; Berg, K; Collins, FS; Furbert-Harris, PM; Bailey-Wilson, JE; Dunston, GM; Powell, I; Carpten, JD

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 67 / 1

Start / End Page

  • 22 - 31

PubMed ID

  • 17031815

Pubmed Central ID

  • 17031815

Electronic International Standard Serial Number (EISSN)

  • 1097-0045

International Standard Serial Number (ISSN)

  • 0270-4137

Digital Object Identifier (DOI)

  • 10.1002/pros.20456


  • eng