Study design for genetic analysis in the Jackson Heart Study.

Published

Journal Article

OBJECTIVE: This paper describes the preparation of genetic materials and the recruitment and initial characterization of a nested Family Study within the Jackson Heart Study (JHS) METHODS: Genomic DNA was prepared from all consenting JHS participants. In addition, family members of a subset of JHS participants were recruited to the JHS Family Study to allow heritability and linkage analyses and family-based association studies. Family Study participants completed the same questionnaires, measures, and procedures as all other JHS participants and provided blood samples for lymphocyte cryopreservation and transformation. RESULTS: DNA samples were obtained from 4726 JHS participants, including 1499 members of 291 families. In the family cohort, estimated heritabilities of body mass index, selected lipid levels, and blood pressure are highly significant, supporting the validity of the sample. DISCUSSION: The JHS data and genetic materials (DNA and cryopreserved cells) offer valuable opportunities to identify susceptibility alleles for common complex diseases by positional and candidate gene approaches.

Full Text

Duke Authors

Cited Authors

  • Wilson, JG; Rotimi, CN; Ekunwe, L; Royal, CDM; Crump, ME; Wyatt, SB; Steffes, MW; Adeyemo, A; Zhou, J; Taylor, HA; Jaquish, C

Published Date

  • January 2005

Published In

Volume / Issue

  • 15 / 4 Suppl 6

Start / End Page

  • S6-30-37 -

PubMed ID

  • 16317983

Pubmed Central ID

  • 16317983

Electronic International Standard Serial Number (EISSN)

  • 1945-0826

International Standard Serial Number (ISSN)

  • 1049-510X

Language

  • eng