Influence of psychological factors on risk of temporomandibular disorders.

Journal Article (Journal Article)

Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 18-34 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.

Full Text

Duke Authors

Cited Authors

  • Slade, GD; Diatchenko, L; Bhalang, K; Sigurdsson, A; Fillingim, RB; Belfer, I; Max, MB; Goldman, D; Maixner, W

Published Date

  • November 2007

Published In

Volume / Issue

  • 86 / 11

Start / End Page

  • 1120 - 1125

PubMed ID

  • 17959908

International Standard Serial Number (ISSN)

  • 0022-0345

Digital Object Identifier (DOI)

  • 10.1177/154405910708601119


  • eng

Conference Location

  • United States