Effects of oxytocin administration on spirituality and emotional responses to meditation.

Journal Article (Journal Article)

The oxytocin (OT) system, critically involved in social bonding, may also impinge on spirituality, which is the belief in a meaningful life imbued with a sense of connection to a Higher Power and/or the world. Midlife male participants (N = 83) were randomly assigned to receive intranasal OT or placebo. In exploratory analyses, participants were also genotyped for polymorphisms in two genes critical for OT signaling, the oxytocin receptor gene (OXTR rs53576) and CD38 (rs6449182 and rs3796863). Results showed that intranasal OT increased self-reported spirituality on two separate measures and this effect remained significant a week later. It also boosted participants' experience of specific positive emotions during meditation, at both explicit and implicit levels. Furthermore, the effect of OT on spirituality was moderated by OT-related genotypes. These results provide the first experimental evidence that spirituality, endorsed by millions worldwide, appears to be supported by OT.

Full Text

Duke Authors

Cited Authors

  • Van Cappellen, P; Way, BM; Isgett, SF; Fredrickson, BL

Published Date

  • October 2016

Published In

Volume / Issue

  • 11 / 10

Start / End Page

  • 1579 - 1587

PubMed ID

  • 27317929

Pubmed Central ID

  • PMC5040919

Electronic International Standard Serial Number (EISSN)

  • 1749-5024

International Standard Serial Number (ISSN)

  • 1749-5016

Digital Object Identifier (DOI)

  • 10.1093/scan/nsw078

Language

  • eng