Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries.

Journal Article (Journal Article;Review)

The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.

Full Text

Cited Authors

  • Mwila, K; Chilengi, R; Simuyandi, M; Permar, SR; Becker-Dreps, S

Published Date

  • January 2017

Published In

Volume / Issue

  • 24 / 1

PubMed ID

  • 27847365

Pubmed Central ID

  • PMC5216432

Electronic International Standard Serial Number (EISSN)

  • 1556-679X

Digital Object Identifier (DOI)

  • 10.1128/CVI.00405-16


  • eng

Conference Location

  • United States