Metabolic Signaling Drives IFN-γ.


Journal Article

IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.

Full Text

Duke Authors

Cited Authors

  • Siska, PJ; Rathmell, JC

Published Date

  • November 8, 2016

Published In

Volume / Issue

  • 24 / 5

Start / End Page

  • 651 - 652

PubMed ID

  • 27829134

Pubmed Central ID

  • 27829134

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2016.10.018


  • eng

Conference Location

  • United States