Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.

Published online

Journal Article

Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose tolerance. In IFNγ-deficient mice, A. muciniphila is significantly increased and restoration of IFNγ levels reduces A. muciniphila abundance. We further show that IFNγ-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFNγ-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFNγ-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFNγ, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans.

Full Text

Duke Authors

Cited Authors

  • Greer, RL; Dong, X; Moraes, ACF; Zielke, RA; Fernandes, GR; Peremyslova, E; Vasquez-Perez, S; Schoenborn, AA; Gomes, EP; Pereira, AC; Ferreira, SRG; Yao, M; Fuss, IJ; Strober, W; Sikora, AE; Taylor, GA; Gulati, AS; Morgun, A; Shulzhenko, N

Published Date

  • November 14, 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 13329 -

PubMed ID

  • 27841267

Pubmed Central ID

  • 27841267

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms13329

Language

  • eng

Conference Location

  • England