Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography.
Journal Article
Background
Myocardial contractility, a significant determinant of cardiac function, is valuable for diagnosis and evaluation of treatment in cardiovascular disorders including heart failure. Shear wave elasticity imaging (SWEI) is a newly developed ultrasound-based elastographic technique that can directly assess the stiffness of cardiac tissue. The aim of this study was to verify the ability of this technique to quantify contractility changes in the myocardium.Methods
In 12 isolated rabbit hearts, SWEI measurements were made of systolic stiffness at five different coronary perfusion pressures from 0 to 92 mm Hg. The changes in coronary perfusion were used to induce acute stepwise reversible changes in cardiac contractility via the Gregg effect. The Gregg effect is the dependency of contractility on coronary perfusion. In four of the hearts, the measurements were repeated after delivery of gadolinium, which is known to block the Gregg effect.Results
Systolic stiffness measured by SWEI changed linearly with coronary perfusion pressure, with a slope of 0.27 kPa/mm Hg (mean of 95% CI, R2 = 0.73). As expected, the change in contractility due to the Gregg effect was blocked by gadolinium, with a significant reduction of the slope to 0.08 kPa/mm Hg.Conclusions
SWEI measurements of systolic stiffness provide an index of contractility in the unloaded isolated rabbit heart. Although this study was done under ideal imaging conditions and with nonphysiologic loading conditions, it reinforces the concept that this ultrasound technique has the potential to provide a direct and noninvasive index of cardiac contractility.Full Text
Duke Authors
Cited Authors
- Vejdani-Jahromi, M; Freedman, J; Nagle, M; Kim, Y-J; Trahey, GE; Wolf, PD
Published Date
- January 2017
Published In
Volume / Issue
- 30 / 1
Start / End Page
- 90 - 96
PubMed ID
- 27843103
Pubmed Central ID
- 27843103
Electronic International Standard Serial Number (EISSN)
- 1097-6795
International Standard Serial Number (ISSN)
- 0894-7317
Digital Object Identifier (DOI)
- 10.1016/j.echo.2016.10.004
Language
- eng