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Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors.

Publication ,  Journal Article
Sarker, S-J; Smith, SK; Chowdhury, K; Ganz, PA; Zimmerman, S; Gribben, J; Korszun, A
Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
March 2017

The aims of this study were to examine quality of life, using the Impact of Cancer version 2 (IOCv2), in British non-Hodgkin lymphoma (NHL) survivors and investigate differences between survivors in the UK and the USA.NHL survivors (326 UK and 667 US) completed the 37-item IOCv2 and psychological distress, fatigue and social support questionnaires.The IOCv2 showed good reliability in the British sample with higher internal consistency (Cronbach alpha 0.7-0.9) and no floor and ceiling effects. UK survivors showed significantly higher negative (p < 0.001) and higher positive (p = 0.003) IOC compared to US survivors. Younger survivors (p = 0.003), those with shorter time since diagnosis (p < 0.001) and with lower levels of social support (p = 0.001), showed more negative IOC in both groups. Higher negative IOC was also significantly associated with fatigue (p < 0.001) and depressive symptoms (p < 0.001) in both countries. Higher positive IOC was associated with female gender (p < 0.001), longer time since diagnosis (p = 0.02), those diagnosed at later stage (p < 0.05) and with greater social support (p = 0.004). Whereas significantly lower positive IOC was associated with white ethnicity (p < 0.001), higher education levels (p < 0.05) and fatigue (p = 0.001).The IOCv2 is reliable and applicable in UK and US populations. Both negative and positive IOC scores were higher in British compared to US survivors. However, in both countries, psychosocial factors consistently showed the greatest impact on QOL irrespective of clinical characteristics. Recognition and treatment of individuals with these risk factors is a high priority for improving QOL in long-term cancer survivors, as is the development of modular interventions aimed at increasing positive IOC as well as decreasing negative impact. The IOCv2 shows great potential both as a screening and assessment measure for examining cancer-related outcomes among survivors.

Duke Scholars

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Published In

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI

EISSN

1433-7339

ISSN

0941-4355

Publication Date

March 2017

Volume

25

Issue

3

Start / End Page

739 / 748

Related Subject Headings

  • United States
  • United Kingdom
  • Survivors
  • Surveys and Questionnaires
  • Social Support
  • Risk Factors
  • Reproducibility of Results
  • Quality of Life
  • Psychometrics
  • Oncology & Carcinogenesis
 

Citation

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ICMJE
MLA
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Sarker, S.-J., Smith, S. K., Chowdhury, K., Ganz, P. A., Zimmerman, S., Gribben, J., & Korszun, A. (2017). Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 25(3), 739–748. https://doi.org/10.1007/s00520-016-3454-1
Sarker, Shah-Jalal, Sophia K. Smith, Kashfia Chowdhury, Patricia A. Ganz, Sheryl Zimmerman, John Gribben, and Ania Korszun. “Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors.Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 25, no. 3 (March 2017): 739–48. https://doi.org/10.1007/s00520-016-3454-1.
Sarker S-J, Smith SK, Chowdhury K, Ganz PA, Zimmerman S, Gribben J, et al. Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2017 Mar;25(3):739–48.
Sarker, Shah-Jalal, et al. “Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors.Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, vol. 25, no. 3, Mar. 2017, pp. 739–48. Epmc, doi:10.1007/s00520-016-3454-1.
Sarker S-J, Smith SK, Chowdhury K, Ganz PA, Zimmerman S, Gribben J, Korszun A. Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2017 Mar;25(3):739–748.
Journal cover image

Published In

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI

EISSN

1433-7339

ISSN

0941-4355

Publication Date

March 2017

Volume

25

Issue

3

Start / End Page

739 / 748

Related Subject Headings

  • United States
  • United Kingdom
  • Survivors
  • Surveys and Questionnaires
  • Social Support
  • Risk Factors
  • Reproducibility of Results
  • Quality of Life
  • Psychometrics
  • Oncology & Carcinogenesis