New facets of antifungal therapy.

Journal Article (Journal Article;Review)

Invasive fungal infections remain a major cause of morbidity and mortality in immunocompromised patients, and such infections are a substantial burden to healthcare systems around the world. However, the clinically available armamentarium for invasive fungal diseases is limited to 3 main classes (i.e., polyenes, triazoles, and echinocandins), and each has defined limitations related to spectrum of activity, development of resistance, and toxicity. Further, current antifungal therapies are hampered by limited clinical efficacy, high rates of toxicity, and significant variability in pharmacokinetic properties. New antifungal agents, new formulations, and novel combination regimens may improve the care of patients in the future by providing improved strategies to combat challenges associated with currently available antifungal agents. Likewise, therapeutic drug monitoring may be helpful, but its present use remains controversial due to the lack of available data. This article discusses new facets of antifungal therapy with a focus on new antifungal formulations and the synergistic effects between drugs used in combination therapy.

Full Text

Duke Authors

Cited Authors

  • Chang, Y-L; Yu, S-J; Heitman, J; Wellington, M; Chen, Y-L

Published Date

  • February 17, 2017

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 222 - 236

PubMed ID

  • 27820668

Pubmed Central ID

  • PMC5354158

Electronic International Standard Serial Number (EISSN)

  • 2150-5608

Digital Object Identifier (DOI)

  • 10.1080/21505594.2016.1257457


  • eng

Conference Location

  • United States