Management of Sedation and Paralysis.

Journal Article (Review)

Sedatives are administered to decrease patient discomfort and agitation during mechanical ventilation and to maintain patient-ventilator synchrony. Titration of infusions and or bolus dosing to maintain light sedation goals according to validated scales is recommended. However, it is important to consider deeper sedation for patients with refractory patient-ventilator dyssynchrony (PVD) to prevent volutrauma and barotrauma. Deep sedation plus muscle relaxants may be required to treat PVD or to reduce oxygen consumption and carbon dioxide production. Although minimization and protocolization of sedation in the intensive care unit improves costs and outcomes, it is important to consider goals on an individual basis.

Full Text

Duke Authors

Cited Authors

  • Fierro, MA; Bartz, RR

Published Date

  • December 2016

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 723 - 739

PubMed ID

  • 27842752

Pubmed Central ID

  • 27842752

Electronic International Standard Serial Number (EISSN)

  • 1557-8216

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2016.07.012


  • eng

Conference Location

  • United States