Moment-to-moment brain signal variability: a next frontier in human brain mapping?

Journal Article (Review;Journal Article)

Neuroscientists have long observed that brain activity is naturally variable from moment-to-moment, but neuroimaging research has largely ignored the potential importance of this phenomenon. An emerging research focus on within-person brain signal variability is providing novel insights, and offering highly predictive, complementary, and even orthogonal views of brain function in relation to human lifespan development, cognitive performance, and various clinical conditions. As a result, brain signal variability is evolving as a bona fide signal of interest, and should no longer be dismissed as meaningless noise when mapping the human brain.

Full Text

Duke Authors

Cited Authors

  • Garrett, DD; Samanez-Larkin, GR; MacDonald, SWS; Lindenberger, U; McIntosh, AR; Grady, CL

Published Date

  • May 2013

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 610 - 624

PubMed ID

  • 23458776

Pubmed Central ID

  • PMC3732213

Electronic International Standard Serial Number (EISSN)

  • 1873-7528

International Standard Serial Number (ISSN)

  • 0149-7634

Digital Object Identifier (DOI)

  • 10.1016/j.neubiorev.2013.02.015


  • eng