Group comparisons: imaging the aging brain.

Published

Journal Article (Review)

With the recent growth of functional magnetic resonance imaging (fMRI), scientists across a range of disciplines are comparing neural activity between groups of interest, such as healthy controls and clinical patients, children and young adults and younger and older adults. In this edition of Tools of the Trade, we will discuss why great caution must be taken when making group comparisons in studies using fMRI. Although many methodological contributions have been made in recent years, the suggestions for overcoming common issues are too often overlooked. This review focuses primarily on neuroimaging studies of healthy aging, but many of the issues raised apply to other group designs as well.

Full Text

Duke Authors

Cited Authors

  • Samanez-Larkin, GR; D'Esposito, M

Published Date

  • September 2008

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 290 - 297

PubMed ID

  • 18846241

Pubmed Central ID

  • 18846241

Electronic International Standard Serial Number (EISSN)

  • 1749-5024

International Standard Serial Number (ISSN)

  • 1749-5016

Digital Object Identifier (DOI)

  • 10.1093/scan/nsn029

Language

  • eng